US EPA

7439455 

Journal Article 

Parenchymal GI Glands: Liver 

Sergi, CM; , 

2020 

Springer Berlin Heidelberg 

Berlin, Heidelberg 

Pathology of Childhood and Adolescence 

425-549 

10.1007/978-3-662-59169-7_4 

http://link.springer.com/10.1007/978-3-662-59169-7_4
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The liver, as one of the most central glands of the body, is the most driving force in the development of the embryo and fetus. The study of the primitive biliary system is crucial for the detection and correct management of numerous cholestasis syndromes of neonatal age and infancy. The explanation of the slowdown period of bile duct morphogenesis between 22 and 32 weeks gestation as well as ductal plate malformation will be an integral part of this chapter. The clarification of the neonatal iron storage disorder as gestational alloimmune liver disease and the identification of numerous molecular mechanisms for familiar intrahepatic cholestasis have been the pillars in the last decade to address the management of these infants. The presentation of several cholestatic liver diseases as well as metabolic disorders is in this chapter and will be accompanied by the introduction of benign, malignant tumors that may target the liver in childhood and youth.