Mallhi, TH; Rasheed, M; Khan, YH; Alzarea, AI; Raja, AA; ,
The exposure of endocrine disrupting chemicals results in disruption of normal energy homeostasis control. Decrease metabolism of carbohydrates, proteins and fats occur due to EDCs induced thyroid dysfunction. The obesogenic and metabolic dysregulation ability leads to development of metabolic disorders. Plasticizers (bisphenol A), persistent organic pollutants (dioxins), organotins (tributyltin), and organochlorines (dichlorodiphenyltrichloroethane) are examples of some EDCs. There has been an increasing focus to investigate association between human exposure to EDCs and disease over the past few decades. Bioactive compounds are found to be effective in these EDCs induced metabolic disorders including diabetes mellitus, hypertension, obesity, hyperlipidemia, and non-alcoholic fatty liver disease. These compounds obtained from fruits, vegetables, and whole grains exert pharmacological effects in humans and play important role in defense and signaling. The use of these compounds is advantageous due to easy availability, safety, and few side effects. The different therapeutic activities of medicinal plants (antioxidants, antiinflammatory, anti-carcinogenic, antimicrobial, anti-malarial, anticholinergic, hypoglycemic, anti-leprosy, and antidiabetic) are basically attributed to the bioactive principles. Polyphenols, phytosterols, carotenoids, prebiotics, vitamins, and flavonoids are effectively used in treating EDCs induced diabetes mellitus, hypertension obesity, hyperlipidemia, and non-alcoholic fatty liver disease.