US EPA

7439672 

Journal Article 

Hormone Excess Syndromes of the Hypothalamic-Pituitary Axis 

Agrawal, N; Kim, H; Wright, K; Mehta, S; , 

2021 

181-213 

10.1007/978-3-030-62187-2_10 

http://link.springer.com/10.1007/978-3-030-62187-2_10
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The pituitary gland in concurrence with the hypothalamus regulates key physiologic processes in the body, including growth, reproduction, metabolism, and water homeostasis. Hypersecretion of trophic hormones, usually due to hormonally active pituitary tumors, causes unique clinical syndromes that can have systemic complications that lead to significant morbidity and mortality. This chapter will provide an overview of the hormone excess syndromes that result from the hypersecretion of prolactin (prolactinomas), adrenocorticotropic hormone (Cushing’s syndrome), growth hormone (acromegaly), thyroid-stimulating hormone (TSHoma), and gonadotropins from the anterior pituitary. Inappropriate hypersecretion of antidiuretic hormone (syndrome of inappropriate antidiuretic hormone) from the posterior pituitary will also be discussed. The focus of this chapter will be on the clinical presentation, diagnosis, and management of each of these syndromes.