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7439688 
Journal Article 
Regulation and Integration of Metabolism During Hypoglycemia 
Da Poian, AT; Castanho, MARB; , 
2021 
Springer International Publishing 
Cham 
Integrative Human Biochemistry 
477-526 
In humans, blood glucose is the main reporter of fed and fasting states. Its concentration directly regulates the secretion of hormones, including glucagon and insulin by the pancreas and glucocorticoids by the adrenal cortex. These hormones, in a coordinated action, regulate the energy metabolism in different organs, allowing the blood concentration of glucose to be maintained within a narrow range by a precise system balancing glucose production by the liver and its utilization by peripheral tissues.