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7441476 
Journal Article 
Mild and efficient dehydration of oximes to nitriles mediated by the Burgess reagent 
Miller, CP; Kaufman, DH 
2000 
1 
Synlett
ISSN: 0936-5214
EISSN: 1437-2096 
8 
1169-1171 
English 
WOS:000088896800024 
Both aliphatic and aromatic aldoximes undergo dehydration to the corresponding nitriles in excellent yields by simply heating the oximes in THF with 1.5 equivalents of the Burgess reagent (methyl N-(triethylammonium-sulfonyl)carbamate,). The reaction also works well using the PEG-supported Burgess reagent and thus has considerable potential for the parallel synthesis of cyano-containing compound libraries. 
Burgess reagent; oxime; nitrile; dehydration; PEG-support 
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