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7442044 
Journal Article 
A MODEL STUDY ON THE SYNTHESIS OF THE MARINE HEPATOTOXIN CYLINDROSPERMOPSIN 
Heintzelman, GR; Parvez, M; Weinreb, SM 
1993 
1 
Synlett
ISSN: 0936-5214
EISSN: 1437-2096 
Georg Thieme Verlag 
STUTTGART 
1993 
8 
551-552 
English 
WOS:A1993LU13800003 
Model diene urea 7 has been converted to the corresponding N-sulfinyl urea 11, which undergoes stereoselective intramolecular hetero [4+2|-cycloaddition to afford dihydrothiazine oxide adduct 12. Treatment of 12 with PhMgBr, followed by stereospecific (2,3]-sigmatropic rearrangement, yields 14 which has the AB ring system and C-7,8 and 10 configuration of cyclindrospermopsin (1). © 1993 Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. 
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