US EPA

7442359 

Journal Article 

PHARMACOLOGICAL STUDY ON A CENTRALLY ACTING MUSCLE RELAXANT (CHLORPHENESIN CARBAMATE) WITH SPECIAL REFERENCE TO EFFECTS ON MOTOR SYSTEMS 

Fukuda, H; Kudo, Y; Ono, H; Kokubo, M 

1974 

1 

Nihon Yakurigaku Zasshi / Folia Pharmacologica Japonica
ISSN: 0015-5691
EISSN: 1347-8397 

70 

3 

341-358 

English 

10.1254/fpj.70.341 

WOS:A1974T827000003 

Effects of 1, 2-propanediol-3-(p-chlorophenoxy)-1-carbamate (chlorphenesin carbamate, CC) on the motor systems were investigated in various animal species. CC decreased grip strength and inhibited cornea and pinna-reflexes in mice. Duration of the protective effects of CC against picrotoxin-, pentylenetetrazol and electro-shocks was longer than that of mephenesin. In addition, tremors induced by oxotremorine in mice were inhibited by CC as in the case of mephenesin. CC had no anti-strychnine effect in mice, whereas mephenesin clearly showed the effect. CC inhibited the spinal functions in rats, chicks and frogs, and the duration of action was longer than that of mephenesin. CC decreased the monosynaptic reflex component as well as polysynaptic component in rats when ventral root potentials were recorded following stimulation of the corresponding dorsal root. Intercollicular and ischemic decerebrate rigidities were depressed by CC as well as mephenesin. Administration of CC, except for large doses, had no effect on the muscle twitches in response to nerve stimulation and the refractory period of muscle twitches. CC caused a decrease of afferent discharges from the muscle spindle of rats in situ and frogs in vitro, which may in part contribute to the muscle relaxant effect of the drug. From these results, it is concluded that CC is a centrally acting muscle relaxant with a longer duration of action and that it differs in nature from mephenesin. © 1974, The Japanese Pharmacological Society. All rights reserved. 

chlorphenesin carbamate; mephenesin; oxotremorine; pentetrazole; picrotoxin; strychnine; carbamic acid derivative; central muscle relaxant; chlorphenesin; mephenesin; oxotremorine; cornea reflex; decerebration; electroconvulsive shock; muscle relaxation; muscle twitch; rigidity; spinal cord; tremor; ventral root potential; animal; article; blood pressure; chicken; contracture; drug effect; electroencephalography; female; frog; guinea pig; hamster; in vitro study; local anesthesia; male; motoneuron; mouse; muscle spindle; neuromuscular synapse; rabbit; rat; reflex; spinal cord; Anesthesia, Local; Animal; Blood Pressure; Carbamates; Chickens; Chlorphenesin; Contracture; Electroencephalography; English Abstract; Female; Guinea Pigs; Hamsters; In Vitro; Male; Mephenesin; Mice; Motor Neurons; Muscle Relaxants, Central; Muscle Spindles; Neuromuscular Junction; Oxotremorine; Rabbits; Rana catesbeiana; Rats; Reflex; Spinal Cord