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7442826 
Journal Article 
Asymmetric synthesis of octahydro-2H-pyrido[1,2-a]-pyrazines 
Froelich, O; Cossart, F; Bonin, M; Quirion, JC; Husson, HP 
1999 
Yes 
Heterocycles
ISSN: 0385-5414 
PERGAMON-ELSEVIER SCIENCE LTD 
OXFORD 
51 
9 
2065-2072 
English 
WOS:000083203500004 
A series of optically pure octahydro-2H-pyrido[1,2-a]pyrazines has been prepared from (-)-2-cyano-6-phenyloxazolopiperidine (4). 2H-Pyrido[1,2-a]pyrazin-3-(4H)-one (7)and octahydro-2H-pyrido[1,2-a]pyrazine (14) were obtained from diamino alcohol (5) by cyclization of bromo- or chloroamides (6) and (10). (4R, 9aS)-1,1,4-Triphenyloctahydro-2H-pyrido[1,2-a]pyrazine (16) was synthesized by cyclization of amino alcohol (15c). The formation of cyclic urea (8aS)-diphenyl-3-oxooctahydroimidazo[1,5-a]pyridine (18) was observed during the hydrogenolysis of the corresponding carbamate (17). 
pyrazine derivative; article; chemical reaction; cyclization; mass spectrometry; synthesis 
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