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7442943 
Journal Article 
Synthesis and biological activity of 2-adamantanone oxime carbamate derivatives 
Georgiev, VS; Bennett, GA; Radov, LA; Kamp, DK; Trusso, LA 
1987 
Yes 
Archiv der Pharmazie
ISSN: 0365-6233
EISSN: 1521-4184 
320 
5 
465-470 
English 
3606351 
WOS:A1987H612300015 
The synthesis of a number of new 2‐adamantanone oxime carbamate derivatives 7a‐h is described. When tested in the carrageenin‐induced rat paw edema assay, some of the compounds exerted moderate anti‐inflammatory activity. In addition, the title 2‐adamantanone oxime carbamates showed in vitro antifungal activity against yeast and systemic mycoses and dermatophytes. Copyright © 1987 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 
2 adamantanone oxime derivative; indometacin; new drug; unclassified drug; animal experiment; biological model; drug analysis; drug comparison; drug identification; drug screening; drug synthesis; drug toxicity; edema; fungus; in vitro study; infrared spectrophotometry; intoxication; nonhuman; nuclear magnetic resonance; oral drug administration; rat; soft tissue; subcutaneous tissue; Adamantane; Animals; Anti-Inflammatory Agents; Antifungal Agents; Carbamates; Chemistry; Oximes; Rats 
Other
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