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7443004 
Journal Article 
DETERMINATION OF THE ENANTIOMERIC PURITY OF (-) 2-(N-PROPYL-N-2-THIENYLETHYLAMINO)-5-HYDROXYTETRALIN (N-0923) BY CHIRAL STATIONARY PHASE HPLC 
Witte, DT; Franke, JP; Swart, PJ; Dezeeuw, RA 
1992 
Yes 
Chirality
ISSN: 0899-0042 
4 
1 
62-64 
English 
WOS:A1992HE02000012 
The determination of the enantiomeric impurity, i.e., the percentage of (+) N−0437 (= N−0924) in several batches of (−−) N‐0437 (= N‐0923) by chiral HPLC is described. Enantiomeric impurities were calculated based on the peak areas of the two baseline separated enantiomers in the chromatogram. The enantiomeric impurities found in different batches ranged from 0.02% to 0.11%. Calibration curves of the two isomers of N‐0437 (Fig. 1,) were made twice to study the reproducibility and linearity of the method. The absorbance ratio, N‐0923/N‐0924, was found to be 1.02 with a relative standard deviation (RSD) of 9% over the whole concentration range used for the calibration curves. Copyright © 1992 Wiley‐Liss, Inc. 
DOPAMINE AGONIST; DIRECT CHIRAL SEPARATION; CELLULOSE CARBAMATE STATIONARY PHASE 
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