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7443634 
Journal Article 
NOVEL HYPOTENSIVE AGENTS, NIAZIMIN-A, NIAZIMIN-B, NIAZICIN-A AND NIAZICIN-B FROM MORINGA-OLEIFERA - ISOLATION OF FIRST NATURALLY-OCCURRING CARBAMATES 
Faizi, S; Siddiqui, BS; Saleem, R; Siddiqui, S; Aftab, K; Gilani, AUH 
1994 
Journal of the Chemical Society, Perkin Transactions 1
ISSN: 1472-7781
EISSN: 1364-5463 
ROYAL SOC CHEMISTRY 
CAMBRIDGE 
20 
3035-3040 
English 
WOS:A1994PP71200022 
Two novel hypotensive carbamate glycosides designated niazimin A 1 and niazimin B 3 and two new hypotensive mustard oil glycosides possessing the thiocarbamate group, niazicin A 5 and niazicin B 10 along with a benzaldehyde;glycoside 12 have been isolated from the fresh leaves extract of Moringa oleifera employing bioassay-guided fractionation. The structures of all these glycosides have been elucidated on the basis of spectroscopic evidence (IR. UV. MS, NMR. 2D NMR) and chemical reactions. Compounds 1 and 3 appear to be the first natural products embodying the carbamate moiety. The amide bond in these compounds appears to play an important role in the hypotensive activity, since in both the carbamates and thiocarbamates it is common to those which possess hypotensive activity. 
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