Active carbonate resins: Application to the solid-phase synthesis of alcohol, carbamate and cyclic peptides | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7444012

Reference Type

Journal Article

Title

Active carbonate resins: Application to the solid-phase synthesis of alcohol, carbamate and cyclic peptides

Author(s)

Alsina, J; Rabanal, F; Chiva, C; Giralt, E; Albericio, F

Year

1998

Is Peer Reviewed?

Journal

Tetrahedron
ISSN: 0040-4020

Volume

Issue

Page Numbers

10125-10152

Language

English

DOI

10.1016/S0040-4020(98)00606-1

Web of Science Id

WOS:000075190800016

Abstract

N,N'-disuccinimidyl carbonate (DSC) has been successfully used to generate carbonates and carbamates on conventional hydroxymethyl and aminomethyl based resins. This methodology extends the applicability of such linkers, which were initially designed for the anchoring of carboxylic acids. Thus, amino and hydroxy groups have been attached onto classical resins to give straightforward access to the solid-phase synthesis of alcohols, carbamates, and cyclic peptides with an evident pharmaceutical interest.

Keywords

combinatorial chemistry; N,N '-disuccinimidyl carbonate (DSC); handle; linker