Mutual binding inhibition of tetrodotoxin and saxitoxin to their binding protein from the plasma of the puffer fish, Fugu pardalis | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7448555

Reference Type

Journal Article

Title

Mutual binding inhibition of tetrodotoxin and saxitoxin to their binding protein from the plasma of the puffer fish, Fugu pardalis

Author(s)

Yotsu-Yamashita, M; Shoji, Y; Terakawa, T; Yamada, S; Miyazawa, T; Yasumoto, T

Year

2002

Is Peer Reviewed?

Yes

Journal

Bioscience, Biotechnology, and Biochemistry
ISSN: 0916-8451
EISSN: 1347-6947

Volume

Issue

Page Numbers

2520-2524

Language

English

PMID

12507001

DOI

10.1271/bbb.66.2520

Web of Science Id

WOS:000179691100038

Abstract

The mutual binding inhibition of tetrodotoxin and saxitoxin to their binding protein from the plasma of Fugu pardalis was investigated by HPLC. The values for the half inhibitory concentration of tetrodotoxin (1.6 microM) binding to this protein (1.2 microM) for saxitoxin, and of saxitoxin (0.47 microM) binding to that (0.30 microM) for tetrodotoxin were 0.35 +/- 0.057 microM and 81 +/- 16 microM (n = 2), respectively.