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7449676 
Journal Article 
Deprotection of a primary Boc group under basic conditions 
Tom, NJ; Simon, WM; Frost, HN; Ewing, M 
2004 
1 
Tetrahedron Letters
ISSN: 0040-4039
EISSN: 1873-3581 
PERGAMON-ELSEVIER SCIENCE LTD 
OXFORD 
45 
5 
905-906 
English 
WOS:000188380400002 
Treatment of a primary t-butyl carbamate (Boc) group with excess sodium t-butoxide in slightly wet tetrahydrofuran or 2-methyltetrahydrofuran provides the corresponding primary amine in excellent yield. We believe the reaction proceeds through ail isocyanate intermediate. (C) 2003 Elsevier Ltd. All rights reserved. 
t-butyl carbamate; Boc; sodium t-butoxide; amine; isocyanate 
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