Synthesis of methyl-N-[4-(3-R-amino-2-hydroxypropoxy)phenyl]carbamates | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7449681

Reference Type

Journal Article

Title

Synthesis of methyl-N-[4-(3-R-amino-2-hydroxypropoxy)phenyl]carbamates

Author(s)

Velikorodov, AV

Year

2004

Is Peer Reviewed?

Journal

Russian Journal of Organic Chemistry
ISSN: 1070-4280
EISSN: 1608-3393

Publisher

MAIK NAUKA/INTERPERIODICA

Location

NEW YORK

Volume

Issue

Page Numbers

188-190

Language

English

DOI

10.1023/B:RUJO.0000034939.01295.42

Web of Science Id

WOS:000222300400005

URL

http://link.springer.com/10.1023/B:RUJO.0000034939.01295.42
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Abstract

By alkylation of methyl-N-(4-hydroxyphenyl) carbamate with (chloroniethyl)oxirane in acetone in the presence of K2CO3 methyl-N-[4-(2,3-epoxypropoxy)phenyl]carbamate was prepared. The aminolysis of the latter effected by benzylamine, morpholine, piperidine, and pyrrolidine occurs in keeping with Krasusky rule to afford methyl-N-[4-(3-R-amino-2-hydroxypropoxy)phenyl]carbamates.

Keywords

(chloromethyl)oxirane; acetone; benzylamine; carbamic acid derivative; ethylene oxide derivative; methyl n (4 hydroxyphenyl)carbamate; methyl n [4 (2 hydroxy 3 morpholinopropoxy)phenyl]carbamate; methyl n [4 (2 hydroxy 3 piperidinopropoxy)phenyl]carbamate; methyl n [4 (2 hydroxy 3 pyrrolidinopropoxy)phenyl]carbamate; methyl n [4 (3 benzylamino 2 hydroxypropoxy)phenyl]carbamate; morpholine; piperidine; potassium derivative; pyrrolidine derivative; unclassified drug; alkylation; aminolysis; article; drug synthesis