US EPA

7449750 

Journal Article 

Organic carbamates in drug development. Part II: antimicrobial agents - recent reports 

Ray, S; Pathak, SA; Chaturvedi, D 

2005 

0 

Drugs of the Future
ISSN: 0377-8282 

30 

2 

161-180 

English 

10.1358/dof.2005.030.02.869228 

WOS:000228252700006 

The continuous evolution of new microbes that are resistant to available antimicrobial agents poses a serious problem in the medical world and presents a challenge for the development of newer agents with a broadened spectrum of activity and improved pharmacological and pharmacokinetic properties. In this area, a number of organic carbamates have emerged in the recent past as potential antibacterial and antiviral agents. The carbamate residue present in such molecules either contributes as a core component or towards improvement of their pharmacological and pharmacokinetic properties. Such compounds include both natural and synthetic products. In this review, recent data on carbamate antibacterial and antiviral agents are discussed. 

1,2,3 triazole derivative; 1,3,4 thiadiazole derivative; a 66321; a 77003; a 80987; aldehyde derivative; amide; amoxicillin; ampicillin; amprenavir; antifungal agent; antiinfective agent; antisense oligonucleotide; antivirus agent; beta lactam antibiotic; bms 182193; carbamic acid derivative; carbapenem derivative; cefalexin; cephalosporin derivative; cethromycin; ciprofloxacin; clarithromycin derivative; eperezolid; erythromycin derivative; ethylamine; gentamicin; hmr 3004; ketolide; ketone derivative; l 685434; l 689502; l 700497; l 738872; linezolid; ly 326188; ly 338387; mutilin; n [[3 (4 acetylphenyl) 2 oxo 5 oxazolidinyl]methyl]acetamide; n [[3 [4 (methylsulfinyl)phenyl] 2 oxo 5 oxazolidinyl]methyl]acetamide; narbomycin; natural product; nelfinavir; norfloxacin; organic compound; oxadiazole derivative; oxazole derivative; oxazolidinone derivative; pikromycin; piperazine derivative; pleuromutilin; pnu 172576; polyamine derivative; proteinase inhibitor; pun 171933; pyridine derivative; pyrrole derivative; quinoline derived antiinfective agent; ritonavir; ro 239424; ro 244383; saquinavir; siderophore; spermidine derivative; spermine derivative; squalamine; sterol derivative; sulfone derivative; tdm 85530; telithromycin; tetrahydrofuran derivative; thiophene derivative; tiamulin; unclassified drug; urethan derivative; zidovudine derivative; antibiotic resistance; antimicrobial activity; clinical trial; diarrhea; drug absorption; drug bioavailability; drug efficacy; drug elimination; drug half life; drug metabolism; drug potency; drug safety; drug screening; drug selectivity; headache; human; human cell; mouse; nonhuman; rash; rat; review; side effect; structure activity relation