Health & Environmental Research Online (HERO)


Print Feedback Export to File
7450031 
Journal Article 
Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3 alpha-YL phenylcarbamate analogs as sigma-2 receptor ligands 
Mach, RH; Vangveravong, S; Huang, YS; Yang, B; Blair, JB; Wu, L 
2002 
Medicinal Chemistry Research
ISSN: 1054-2523
EISSN: 1554-8120 
Birkhauser Boston 
11 
380-398 
English 
Aseries of N-substituted-9-azabicyclo[3.3.1]nonan-3α-yl)carbamate analogs was prepared and their affinities for sigma (σ1 and σ2) receptors was measured in vitro. The results of this structure-activity relationship study identified a novel compound, N-(9-(4-aminophenethyl))-9-azabicyclo[3.3.1]nonan-3α-yl)-N′- (2-methoxy-5-methylphenyl)carbamate (2f), having a high affinity and excellent selectivity for σ2 versus σ1receptors. This compound should be a useful ligand for characterizing the functional role of σ2 receptors in vivo. 
9 aza bicyclo[3.3.1]nonan 3alpha ylphenylcarbamate derivative; bicyclo compound; carbamic acid derivative; ligand; n [9 (4 aminophenethyl) 9 azabicyclo[3.3.1]nonan 3alpha yl] n' (2 methoxy 5 methylphenyl)carbamate; sigma 1 opiate receptor; sigma 2 opiate receptor; sigma opiate receptor; unclassified drug; animal tissue; article; binding affinity; drug receptor binding; drug selectivity; drug synthesis; in vitro study; male; nonhuman; rat; structure activity relation 
Other
• Harmful Algal Blooms- Health Effects
     April 2021 Literature Search
          WOS
          Scopus
          Saxitoxins
               WOS