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Citation
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HERO ID
7450031
Reference Type
Journal Article
Title
Synthesis of N-substituted 9-azabicyclo[3.3.1]nonan-3 alpha-YL phenylcarbamate analogs as sigma-2 receptor ligands
Author(s)
Mach, RH; Vangveravong, S; Huang, YS; Yang, B; Blair, JB; Wu, L
Year
2002
Is Peer Reviewed?
1
Journal
Medicinal Chemistry Research
ISSN:
1054-2523
EISSN:
1554-8120
Publisher
Birkhauser Boston
Volume
11
Issue
7
Page Numbers
380-398
Language
English
Web of Science Id
WOS:000183116200002
Abstract
Aseries of N-substituted-9-azabicyclo[3.3.1]nonan-3α-yl)carbamate analogs was prepared and their affinities for sigma (Ï1 and Ï2) receptors was measured in vitro. The results of this structure-activity relationship study identified a novel compound, N-(9-(4-aminophenethyl))-9-azabicyclo[3.3.1]nonan-3α-yl)-Nâ²- (2-methoxy-5-methylphenyl)carbamate (2f), having a high affinity and excellent selectivity for Ï2 versus Ï1receptors. This compound should be a useful ligand for characterizing the functional role of Ï2 receptors in vivo.
Keywords
9 aza bicyclo[3.3.1]nonan 3alpha ylphenylcarbamate derivative; bicyclo compound; carbamic acid derivative; ligand; n [9 (4 aminophenethyl) 9 azabicyclo[3.3.1]nonan 3alpha yl] n' (2 methoxy 5 methylphenyl)carbamate; sigma 1 opiate receptor; sigma 2 opiate receptor; sigma opiate receptor; unclassified drug; animal tissue; article; binding affinity; drug receptor binding; drug selectivity; drug synthesis; in vitro study; male; nonhuman; rat; structure activity relation
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