Synthesis and biological activity of methyl N-methoxy-N-[2-(1,6-dihydro-1-substituent-6-oxo-pyridazin-3-yloxymethyl)phenl]carbamates | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7450793

Reference Type

Journal Article

Title

Synthesis and biological activity of methyl N-methoxy-N-[2-(1,6-dihydro-1-substituent-6-oxo-pyridazin-3-yloxymethyl)phenl]carbamates

Author(s)

Liu, WD; Li, ZW; Li, ZY; Wang, XG; Gao, BD

Year

2005

Is Peer Reviewed?

Journal

Youji Huaxue / Chinese Journal of Organic Chemistry
ISSN: 0253-2786

Volume

Issue

Page Numbers

445-448

Language

Chinese

Web of Science Id

WOS:000228201900017

Abstract

In an attempt to find novel compounds with high activity and low toxicity, a series of novel methyl N-methoxy-N-[2-(1,6-dihydro-1-substituent-6-oxo- pyridazin-3-yloxymethyl)phenyl]carbamate derivatives 3a-3k were designed and synthesized by bioisoster principle. Their structures were confirmed by 1H NMR, IR, LC/MS spectra and elemental analysis. The preliminary biological activity tests show that some compounds possess fungicidal activities against Pyricularia oryzae, Botrytis cinerea and Erysiphe graminis.

Keywords

pyridazinone; N-methoxylcarbamate; synthesis; fungicidal activity