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7452297 
Journal Article 
Synthesis of macrocyclic urea kinase inhibitors 
Tao, Z; Sowin, TJ; Lin, N 
2007 
1 
Synlett
ISSN: 0936-5214
EISSN: 1437-2096 
18 
2855-2858 
English 
WOS:000251507000018 
An efficient and convergent route was developed for the synthesis of a novel class of urea-based macrocyclic kinase inhibitors. The synthesis is featured with an efficient urea formation by using a key carbamate intermediate and with a smooth ring-closure olefin metathesis. Furthermore, the hydrogenations of the resulting olefins were investigated in this complex macrocyclic ring system. © Georg Thieme Verlag Stuttgart. 
metathesis; urea; macrocycles; hydrogenations; kinase inhibitors 
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