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7456141 
Journal Article 
Synthesis and characterization of Tenofovir disoproxil fumarate impurities, anti HIV drug substance 
Varal, D; Joshi, M; Panmand, D; Jadhav, V 
2016 
Scholars Research Library 
8 
1 
338-343 
English 
In the process development of Tenofovir disoproxil fumarate specified known, specified unknown and unidentified impurities found. The present work describes synthesis and characterizations of USP related known and unknown impurities; mono-POC Tenofovir (5), mono-POC methyl Tenofovir (6a), mono-POC ethyl Tenofovir, (6b), mono- POC isopropyl Tenofovir (6c), Tenofovir isopropyl isoproxil (7) and Tenofovir disoproxil carbamate (9). Identification of these impurities can be useful for quality control purpose in the manufacture of Tenofovir disoproxil fumarate. 
Antiretroviral tenofovir disoproxil fumarate; Characterization; Impurity synthesis; chemical compound; mono isopropyloxycarbonylmethyl ethyl tenofovir; mono isopropyloxycarbonylmethyl isopropyl tenofovir; mono isopropyloxycarbonylmethyl methyl tenofovir; mono isopropyloxycarbonylmethyl tenofovir; tenofovir disoproxil; tenofovir disoproxil carbamate; tenofovir disoproxil fumarate impurity; tenofovir isopropyl isoproxil; unclassified drug; Article; chemical analysis; controlled study; drug impurity; drug manufacture; infrared spectroscopy; mass spectrometry; proton nuclear magnetic resonance; quality control; structure analysis; synthesis 
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