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7456265 
Journal Article 
Study on synthesis of (R)-tert-butyl benzyl(1-((tert-butyldimethylsilyl)oxy)but-3-yn-2-yl)carbamate 
Tang, LJ; Liu, DW; Qin, SL; Wang, LP; Li, YP; Huang, SP; Wang, XJ 
2014 
Yes 
Advanced Materials Research
ISSN: 1022-6680 
Trans Tech Publications Ltd 
4th International Conference on Chemical Engineering and Advanced Materials, CEAM 2014 
1033-1034 
592-595 
English 
(R)-tert-butyl (1-hydroxybut-3-yn-2-yl)carbamate, an intermediate of the natural product jaspine B, which was isolated from various sponges and endowed with cytotoxic activity against several human carcinoma cell lines, was synthesized from L-Serine in overall yield 30% through seven steps, including esterification, Bn protection, Boc protection, TBS protection, reduction, Corey-Fuchs reaction. © (2014) Trans Tech Publications, Switzerland. 
(R)-tert-butyl benzyl(1-((tert-butyldimethylsilyl)oxy)but-3-yn-2-yl)carbamate; Jaspine B; L-serine; Synthesis; Amino acids; Cell culture; Cytotoxicity; Reaction intermediates; Boc protection; Cytotoxic activities; Human carcinoma cell line; L-serine; Natural products; Tert-butyldimethylsilyl; Synthesis (chemical) 
Xiao H. 
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