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7457397 
Journal Article 
A facile construction of 5-methylazido-3-aryl 2-oxazolidinone: A key precursor for the synthesis of Linezolid 
Venkanna, G; Madhusudhan, G; Mukkanti, K; Sampath Kumar, Y; Venu, K 
2012 
4 
1 
428-436 
English 
A facile construction of 5-methylazido-3-Aryl 2-Oxazolidinone is derived from various1-azido-3-chloro-2-aryl/alkyl carbonates derivative and this extended to syntheses of Linezolid, an antibacterial agent are reported. The key step in the approached involves addition of 3-fluoro-4-morpholinobenzenamine with respective compounds by changing the leavingfunctionalities carbamate followed by formation of 2-oxazolidnone on other end and followed byfunctional group transformations yielded an antibacterial agent Linezolid. Process and lessnumber of steps. 
5-methylazido-3-Aryl 2-Oxazolidinone; Antibacterial agent; Linezolid; Various carbamates; 5 (aminomethyl) 3 (3 fluoro 4 morpholinophenyl)oxazolidine 2 one; 5 methylazido 3 aryl 2 oxazolidone; linezolid; oxazolidine derivative; oxazolidinone derivative; unclassified drug; article; carbon nuclear magnetic resonance; chemical reaction kinetics; column chromatography; controlled study; drug isolation; drug structure; drug synthesis; infrared spectroscopy; intermethod comparison; proton nuclear magnetic resonance; thin layer chromatography 
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