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HERO ID
7457892
Reference Type
Journal Article
Title
Light- and pH-responsive release of doxorubicin from a mesoporous silica-based nanocarrier
Author(s)
Kneå¾Eviä, NZ; Trewyn, BG; Lin, VSY
Year
2011
Is Peer Reviewed?
Yes
Journal
Chemistry: A European Journal
ISSN:
0947-6539
EISSN:
1521-3765
Volume
17
Issue
12
Page Numbers
3338-3342
Language
English
DOI
10.1002/chem.201002960
Abstract
Shining light for drug delivery: The anticancer drug doxorubicin (Dox, red ellipses in the graphic) was adsorbed on nitroveratryl carbamate-protected aminopropyl-functionalized mesoporous silica nanoparticles (MSNs). Upon exposure to UV light, positively charged propylammonium moieties were formed on the surface, which caused expulsion of positively charged Dox molecules from the surface of the nanoparticles. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords
doxorubicin; drug delivery; mesoporous materials; nanoparticles; photosensitive; Aminopropyl; Anticancer drug; Doxorubicin; Functionalized; Mesoporous; Mesoporous Silica; Mesoporous silica nanoparticles; Nanocarriers; PH-responsive; photosensitive; Positively charged; UV light; Drug delivery; Light sensitive materials; Nanoparticles; Photosensitivity; Silica; Mesoporous materials; antineoplastic agent; doxorubicin; nanoparticle; silicon dioxide; article; chemistry; drug delivery system; light; methodology; pH; porosity; Antineoplastic Agents; Doxorubicin; Drug Delivery Systems; Hydrogen-Ion Concentration; Light; Nanoparticles; Porosity; Silicon Dioxide
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