US EPA

7458258 

Journal Article 

Synthesis and antioxidant activity of some albendazole derivatives 

El Harti, J; Doudach, L; Faouzi, MA; Taoufik, J; Ansar, M 

2014 

6 

2 

781-784 

English 

The new benzimidazole derivatives were synthesized from the albendazole. The compounds thus prepared were characterized by their physical (TLC, M.P) and spectral data (IR and NMR). Then the compounds were screened for antioxidant activity. Among the five derivatives which were synthesized, one product showed a significant antioxidant activity. 

Antioxidant activity; Benzimidazole; Synthesis; Albendazole; Anti-oxidant activities; Benzimidazole derivatives; Benzimidazoles; Spectral data; Pharmacodynamics; Synthesis (chemical); Medicine; albendazole; benzimidazole derivative; methyl (1 (3,5 dinitrobenzoyl) 5 (propylthio) 1H benzo[d]imidazol 2 yl) carbamate; methyl (1 (4 chlorobenzoyl) 5 (propylthio) 1H benzimidazol 2 yl) carbamate; methyl (1 (4 fluorobenzoyl) 5 (propylthio) 1H benzo[d]imidazol 2 yl) carbamate; methyl (1 (4 methoxybenzoyl) 5 (propylthio) 1H benzo[d]imidazol 2 yl) carbamate; methyl (1 benzoyl 5 (propylthio) 1H benzo[d]imidazol 2 yl) carbamate; trolox C; unclassified drug; antioxidant activity; article; DPPH radical scavenging assay; drug synthesis; infrared spectrometry; nuclear magnetic resonance spectroscopy; proton nuclear magnetic resonance; thin layer chromatography