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7458952 
Book/Book Chapter 
Chapter 1 - Oxidative eustress and oxidative distress: Introductory remarks 
Sies, H 
2020 
Academic Press 
Oxidative Stress 
3-12 
In the research area of redox biology, the concept of oxidative stress encompasses redox imbalance, affecting redox signaling and leading to damage of biomolecules. Stress response systems can counteract, restoring redox balance. Normal metabolism and functions maintaining steady state require low levels of oxidants, denoted as oxidative eustress. Supraphysiological oxidant challenge is denoted as oxidative distress. Oxidative stress is generated endogenously (cell metabolism) and exogenously (exposome). Fundamental life processes and diseases have an oxidative stress component, opening the field for research on redox medicine. 
Redox biology; Oxidants; Antioxidants; Stress response; Disease; Metabolism; Exposome 
Sies, Helmut