US EPA

7470860 

Journal Article 

Medicinal attributes of imidazo[1,2-a]pyridine derivatives: An update 

Devi, N; Singh, D; Rawal, RK; Bariwal, J; Singh, V 

2016 

Yes 

Current Topics in Medicinal Chemistry
ISSN: 1568-0266 

Bentham Science Publishers B.V. 

16 

26 

2963-2994 

English 

10.2174/1568026616666160506145539 

The imidazo[1,2-a]pyridine scaffold is recognized as a privileged structure as it represents a promising area for identification of lead structures towards the discovery of new synthetic drug molecules. Several commercial drugs such as Zolpidem, Olprinone, Soraprazan and many other compounds in biological testing and preclinical evaluation, illustrate the wide therapeutic spectrum in this class of drug scaffolds. The present manuscript represents the assimilation of literature pertaining to medicinal aspects of this pharmacophore including the structure-activity relationships. © 2016 Bentham Science Publishers. 

Groebke-Blackburn-Bienayme reaction; Imidazo[1,2-a]pyridine; Multicomponent reaction; N-fused imidazole; SAR; Ugi type; 2 (5 substituted) 1,3,4 oxadiazole 2 yl) h imidazo[1,2 a]pyridine derivative; 2 amino 3 substituted 6 [(e) 1 phenyl 2 (N methyl carbamoyl)vinyl] imidazo[1,2 a] pyridine derivative; 2 aryl 3 [2 aminopyrimidin 4 yl] imidazopyridine derivative; 2 [(4 phenylpiperazin 1 yl)methyl] imidazoazine pyridine derivative; 3 (1 [(4 fluorophenyl)sulfonyl] 1h pyrazol 3 yl) 2 methylimidazo [1,2 a] pyridine derivative; 6 substituted 2 (h trifluoroacetylamino)imidazo pyridine derivative; 6 substituted methyl imidazo[1,2 a]pyridine 2 carbamate derivative; antileishmanial agent; bromodomain inhibitor; coccidiostatic agent; cyclin dependent kinase; DNA topoisomerase (ATP hydrolysing); growth factor receptor; imidazo [1,2 a] pyridine derivative; imidazo[1,2 a]pyridin 3 amine derivative; imidazo[1,2 a]pyridine 8 carboxamide derivative; imidazo[1,2 a]pyridine amide derivative; imidazo[1,2 a]pyridine derivative; interleukin 1 receptor associated kinase 4; kinesin; n,n dialkyl 2 phenylimidazo[1,2 a]pyridine 3 acetamide derivative; n,n dialkyl 2 phenylimidazo[1,2 a]pyridine 3 propionamide derivative; nicotinamide phosphoribosyltransferase; peptides and proteins; phosphatidylinositol 3 kinase; soraprazan; unclassified drug; unindexed drug; vasculotropin receptor 2; zolpidem; [6 iodo 2 (4 n,n dimethylamino) phenylimidazo[1,2 a]pyridine] derivative; antiinfective agent; DNA; imidazole derivative; pyridine derivative; Alzheimer disease; anthelmintic activity; antibacterial activity; anticonvulsant activity; antidiabetic activity; antifungal activity; antiinflammatory activity; antimalarial activity; antineoplastic activity; antiproliferative activity; antiulcer activity; antiviral activity; Article; clinical trial (topic); drug activity; drug screening; human; insecticidal activity; nonhuman; nucleoside transport; oxidative coupling; structure activity relation; chemistry; drug effects; Anti-Infective Agents; DNA; Imidazoles; Pyridines; Structure-Activity Relationship