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7476612 
Journal Article 
Review 
A contemporary review of male breast cancer: current evidence and unanswered questions 
Leon-Ferre, RA; Giridhar, KV; Hieken, TJ; Mutter, RW; Couch, FJ; Jimenez, RE; Hawse, JR; Boughey, JC; Ruddy, KJ 
2018 
Yes 
Cancer and Metastasis Reviews
ISSN: 0167-7659
EISSN: 1573-7233 
37 
4 
599-614 
English 
30232577 
WOS:000457482700004 
Male breast cancer is rare, accounting for 1% of all breast cancer diagnoses in the USA. Because of its rarity, most major breast cancer trials have included only female patients. This has resulted in limited prospective data to guide the clinical management of men with breast cancer. As a result, treatment decisions are typically extrapolated from data generated in female patients. This approach may be suboptimal, particularly considering the differing hormonal milieus between men and women with respect to both breast cancer development and treatment. Herein, we summarize current knowledge of the biology and clinicopathology of male breast cancer and review current approaches to locoregional and systemic management of this rare disease. 
Male breast cancer; BRCA; Epidemiology; Surgery; Endocrine therapy; Chemotherapy; Radiation therapy