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7479223 
Journal Article 
Chiral separation of 3,4-dihydropyrimidin-2(1h)-ones and 3,4-di-hydro-pyrimidin-2(1h)-thiones enantiomers by HPLC on chiralcel®od-h 
Kichou, N; Rahou, I; Elamin, ZM; Sekkoum, K; Belboukhari, N; Bechki, L; Aboul-Enein, HY 
2020 
Yes 
Current Analytical Chemistry
ISSN: 1573-4110 
Bentham Science Publishers 
16 
3 
250-255 
English 
Objective: Ten racemic 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones were separated by liquid chromatography on Chiralcel®OD-H column containing cellulose tris(3, 5-dimethylphenylcarbamate). Methods: The enantioseparation was carried out using Chiralcel®OD-H polysaccharide-type chiral stationary phase to resolve such enantiomers under normal-phase mode. Results: Complete separations of the 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones derivatives with good resolution (RS= 1.04-2.80) were achieved within a short time (10-15 min). Conclusion: An optimal baseline separation (Rs> 1.5) was achieved using Chiralcel®OD-H under normal-phase mode. Structure-retention relationships have also been discussed. © 2020 Bentham Science Publishers. 
3,4-dihydropyrimidin-2(1H)-ones; 3,4-dihydropyrimidin-2(1H)-thiones; 5-dimethylphenyl-carbamate); Chiral separation; Chiralcel®OD-H; HPLC; Tris(3 
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