US EPA

7482422 

Journal Article 

Malignant Mesothelioma: Pathology 

Anttila, S; , 

2020 

Springer International Publishing 

Cham 

Occupational Cancers 

303-318 

English 

10.1007/978-3-030-30766-0_17 

http://link.springer.com/10.1007/978-3-030-30766-0_17
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The majority of malignant mesotheliomas (MMs) occur in the pleura, but they may also arise in the peritoneum, the pericardium, or the tunica vaginalis testis. MM is a great mimic and its morphology is so variable that a vast number of different primary and secondary tumors of the body cavities must be considered in differential diagnosis. Another diagnostic challenge is distinguishing MM from reactive lesions, i.e., epithelioid MM from benign mesothelial hyperplasia and sarcomatoid or desmoplastic MM from fibrous pleuritis. Molecular markers, such as loss of BAP1 and homozygous deletion of 9p21 chromosomal region, have a specificity of 100% and, if combined, a sensitivity of appr. 80% in the diagnosis of malignant mesothelioma. Diffuse MM exhibiting any subtype or morphological pattern may have asbestos etiology. © Springer Nature Switzerland AG 2020. 

Cytology; Immunohistochemistry; Malignant mesothelioma; Mesothelioma diagnosis; Mesothelioma subtypes; Pathology