US EPA

7491747 

Journal Article 

Zaviralci ureaze 

Frlan, R 

2013 

0 

Farmacevtski Vestnik
ISSN: 0014-8229 

64 

3 

218-226 

Slovenian 

Urease is an enzyme that catalyzes the hydrolysis of urea to ammonia and carbamate. Ureolytic activity of human pathogens, such as Helicobacter pylori, Proteus spp. and others is thought to be a causative factor of many clinical conditions, such as peptic ulcer and urinary infection stones. The most efficient therapy which is quite successful at the moment is complete eradication of bacteria and treatment of disease symptoms. Because of the increasing resistance to antibacterial agents the design of new treatment routes is becoming a new focal point to control these diseases in the future. One of perspective targets in the design of novel inhibitors and vaccines is urease. Many inhibitors have been developed so far, however only one compound, acetohydroxamic acid, has been used clinically for the treatment of urinary tract infections. Copyright © 2013, OceanSide Publications, Inc., U.S.A. 

Helicobacter pylori; Inhibitors; Peptic ulcer; Ureases; Urinary stones; acetohydroxamic acid; ammonia; antiinfective agent; carbamic acid; urease inhibitor; bacterial clearance; catalysis; Helicobacter pylori; human; nonhuman; peptic ulcer; Proteus; review; urinary tract infection