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7493358 
Journal Article 
Specific synthesis of 1-substituted phenothiazines using carbon dioxide protection of the NH group during lithiation 
Katritzky, AR; De Miguel, LMV; Rewcastle, GW 
1988 
1 
Synthesis
ISSN: 0039-7881
EISSN: 1437-210X 
Georg Thieme Verlag 
1988 
3 
215-217 
English 
The lithiation of phenothiazine when protected as the lithium salt of its carbamate occurs exclusively at the C-1 carbon atom. Reaction of the lithiated species with a variety of electrophiles readily produced several new 1-substituted phenothiazines, as well as a number of known compounds in superior yield to existing methods. © 1988 Georg Thieme Verlag. All rights reserved. 
phenothiazine derivative; drug analysis; methodology; nonhuman; nuclear magnetic resonance 
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