Chromatographic Studies in Relation to Ethyl Carbamate (Urethan) Carcinogenesis Using Cu-labeled Compounds | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7493426

Reference Type

Journal Article

Title

Chromatographic Studies in Relation to Ethyl Carbamate (Urethan) Carcinogenesis Using Cu-labeled Compounds

Author(s)

Kaye, AM

Year

1960

Is Peer Reviewed?

Yes

Journal

Cancer Research
ISSN: 0008-5472
EISSN: 1538-7445

Volume

Issue

Page Numbers

44-49

Language

English

Abstract

Paper chromatographic studies were made on (a) plasma from rabbits given injections of methyl- or carbonyl-C14-labeled urethan 2Â½ and 3Â½ hours previously, (b) mouse plasma obtained 2Â½, 6, or 12 hours after injection of urethan-C14, and (c) urethan-C14 solutions in which mouse lung, liver, and skin had been incubated. Precautions were taken against loss of urethan or of similarly volatile compounds. The methods developed included a procedure for the direct hydrolysis of carbonyl-C14-urethan to C14O2 without elution from the paper strip. In all cases only a single migrating component was found, whose rate of migration and volatility corresponded to those of free urethan. This study, therefore, suggests that there is no specific metabolite of urethan which could be involved in urethan carcinogenesis. Â© 1960, American Association for Cancer Research. All rights reserved.

Keywords

carcinogen; urethan; article; CARCINOGENS/chemistry; chemistry; experimental neoplasm; NEOPLASMS/experimental; URETHANE/pharmacology; CARCINOGENS/chemistry; NEOPLASMS/experimental; URETHANE/pharmacology; Carcinogens; Neoplasms, Experimental; Urethane