1085-1090,in3-in4,1091-1092
The carbamate cholinesterase inhibitor physostigmine (eserine) has been shown to produce effects on the smooth muscle of the toad which cannot be attributed to its anticholinesterase activity. These effects are a depression of excitatory responses to cholinergic nerve stimulation and applied choline esters, and contraction of the muscle. The first of these phenomena has been attributed to an attropinic action of physostigmine at muscarinic receptors on the muscle cell, and the second to enhanced release of acetylcholine from nerve endings. © 1966.
acetylcholine; atropine; biphenyl derivative; carbachol; dyflos; ganglion blocking agent; physostigmine; potassium; animal; article; bladder; cholinergic system; drug effect; electrostimulation; frogs and toads; male; muscle; muscle contraction; nerve ending; pH; physiology; sensory receptor; smooth muscle; Acetylcholine; Animal; Anura; Atropine; Biphenyl Compounds; Bladder; Carbachol; Electric Stimulation; Ganglionic Blockers; Hydrogen-Ion Concentration; Isoflurophate; Male; Muscle Contraction; Muscle, Smooth; Muscles; Nerve Endings; Parasympathetic Nervous System; Physostigmine; Potassium; Receptors, Sensory