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7494033 
Journal Article 
Influence of Derivatisation of the Hydroxy Groups in 1,1‐Bis‐(4‐hydroxyphenyl)‐2‐phenylbut‐1‐ene on Estradiol Receptor Affinity and Mammary Tumor Inhibiting Properties 
Schuderer, ML; Schneider, MR 
1987 
Yes 
Archiv der Pharmazie
ISSN: 0365-6233
EISSN: 1521-4184 
320 
7 
635-641 
English 
The phenolic hydroxy groups of 1,1‐bis‐(4‐hydroxyphenyl)‐2‐phenylbut‐1‐ene (1) were converted to esters of different chain length and degree of halogen substitution, and to carbamate, imidoester and ether derivatives. Most of the products maintain the affinity to the estrogen receptor. The acetate 2 has a better antitumor potency than 1. Copyright © 1987 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 
1,1 bis(4 acetoxyphenyl) 2 phenyl 1 butene; 1,1 bis(4 hydroxyphenyl) 2 phenyl 1 butene; 1,1 bis(4 hydroxyphenyl) 2 phenyl 1 butene derivative; estradiol h 3; unclassified drug; animal cell; animal experiment; animal model; breast; cancer chemotherapy; cattle; drug comparison; drug efficacy; drug receptor binding; drug stability; drug structure; drug synthesis; female genital system; mouse; nonhuman; nuclear magnetic resonance; structure activity relation; subcutaneous drug administration; therapy; Animal; Antineoplastic Agents; Cattle; Chemistry; Estradiol; Female; In Vitro; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Receptors, Estrogen; Stilbenes; Support, Non-U.S. Gov't 
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