Katritzky, AR; Shestopalov, AA; Suzuki, K
Diverse thiol esters were synthesized in good to excellent yields (76-99%) by reactions of thiophenol, benzyl mercaptan, ethyl mercaptoacetate, and mercaptoacetic acid with N-acylbenzotriazoles under mild conditions. These results demonstrate the utility of N-acylbenzotriazoles as mild S-acylating agents, especially when the corresponding acid chlorides are not readily available.
Acylating agent; Benzotriazole methodology; N-acylbenzotriazoles; S-acylation; Thiol esters; Acetic acid; Acylation; Alcohols; Aromatic compounds; Reaction kinetics; Synthesis (chemical); Benzyl mercaptan; Mercaptoacetic acids; Thiol esters; Esters; 1h 1,2,3 benzotriazol 1 yl 1h indol 2 ylmethanone; 1h 1,2,3 benzotriazol 1 yl 2 furylmethanone; 1h 1,2,3 benzotriazol 1 yl 2 methoxyphenylmethanone; 1h 1,2,3 benzotriazol 1 yl 2 pyridinylmethanone; 1h 1,2,3 benzotriazol 1 yl 4 diethylaminophenylmethanone; 1h 1,2,3 benzotriazol 1 yl [3 (1h 1,2,3 benzotriazol)] 1 ylcarbonylphenylmethanone; 1h 1,2,3 benzotriazol 1 ylphenylmethanone; 2 [(2 methoxybenzoyl)sulfanyl]acetic acid; benzotriazole derivative; benzoylmercaptoacetic acid; benzyl n [2 (1h 1,2,3 benzotriazol 1yl) 1 benzyl 2 oxoethyl]carbamate; benzyl n [2 [[2 (1h 1,2,3 benzotriazol 1 yl)] 1 methyl 2 oxoethyl]amino 1 benzyl 2 oxoethyl]carbamate; ethyl 2 benzoylsulfanylacetate; ethyl [2 (2 methoxybenzoyl)sulfanyl]acetate; s benzyl 1h indole 2 carbothioate; s benzyl 2 furancarbothioate; s benzyl 2 methoxybenzenecarbothioate; s benzyl 2 pyridinecarbothioate; s benzyl 4 diethylaminobenzenecarbothioate; s benzylbenzenecarbothioate; s phenyl 1h indole 2 carbothioate; s phenyl 2 furancarbothioate; s phenyl 2 methoxybenzenecarbothioate; s phenyl 2 pyridinecarbothioate; s phenyl 4 diethylaminobenzenecarbothioate; s phenylbenzenecarbothioate; s1,s3 dibenzyl 1,3 benzenedicarbothioate; s1,s3 diphenyl 1,3 benzenedicarbothioate; tert butyl n [2 (1h 1,2,3 benzotriazol 1 yl) 1 benzyl 2 oxoethyl]carbamate; thioester; unclassified drug; acylation; article; chemical reaction; synthesis