US EPA

7500618 

Journal Article 

Effects of CO2, and diphosphoglycerate on foetal blood affinity for oxygen 

Bursaux, E; Freminet, A; Poyart, C 

1974 

1 

Respiration Physiology
ISSN: 0034-5687 

20 

2 

181-189 

English 

10.1016/0034-5687(74)90106-6 

The specific effect of carbon dioxide on blood affinity for oxygen (P50 at pH 7.2) and on the Bohr effect (Δ log P50/ΔpH) has been measured in adult and cord blood in the presence (fresh blood) and the absence (stored blood) of 2,3-diphosphoglycerate (DPG). Studies were performed without C02 and at a P50, of 40 torr at 37 °C. Blood pH was varied with fixed acid (HC1) and base NaOH) from 6.8 to 7:4. Carbon dioxide lowers the Bohr coefficients similarily in cord and adult blood; this effect is 50% inhibited by DPG. In the absence of DPG, the CO 2 specific effect on P50 is lower in cord blood than in adult blood. DPG increases P50 less in cord blood than in adult blood. In cord blood the DPG and CO2 effects are additive. The higher affinity of foetal blood for oxygen may be explained by the lower response of foetal haemoglobin to CO5 and DPG. This is considered as an example of physiological adaptation of foetal erythrocytes to the conditions of intra-uterine life. © 1974. 

2,3 Diphosphoglycerate; Bohr effect; Carbamate; Carbon dioxide; Foetal blood; Foetal haemoglobin; P50 at pH 7.2; 2,3 diphosphoglyceric acid; carbamic acid; carbon dioxide; hemoglobin; hemoglobin f; oxygen; 2,3 diphosphoglyceric acid; hemoglobin F; oxygen; oxyhemoglobin; bohr effect; erythrocyte; fetus; fetus blood; hematology; newborn; normal human; oxygen affinity; oxygen dissociation curve; pediatrics; ph; theoretical study; umbilical cord blood; article; blood; erythrocyte; female; hemoglobin determination; human; metabolism; pH; pregnancy; pressure; umbilical cord; vascularization; Carbon Dioxide; Diphosphoglyceric Acids; Erythrocytes; Female; Fetal Hemoglobin; Hemoglobinometry; Human; Hydrogen-Ion Concentration; Oxygen; Oxyhemoglobins; Partial Pressure; Pregnancy; Umbilical Cord