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7500912 
Journal Article 
Brunette to Blonde Depigmentation of Human Hair During Oral Treatment with Mephenesin 
Spillane, JD 
1963 
Yes 
British Medical Journal
ISSN: 0007-1447 
1 
5336 
997-1000 
English 
Mephenesin (” myanesin “) carbamate can cause depigmentation of scalp hair. The effect has been observed in six patients—four female and two male. Five were suffering from multiple sclerosis and one from a post-traumatic hemiplegia. The degree of depigmentation seems to depend on the dosage of the drug and the duration of treatment. In the most striking cases the hair turned from dark brown to blonde in three months when the patients were taking 20 tablets (10 g.) daily. There were no general ill-effects and the colour change was much appreciated by the four women patients, who seemed inclined to keep it a secret. The manner in which mephenesin exerts this effect on melanogenesis is not known, but experimental studies are being undertaken. © 1963, British Medical Journal Publishing Group. All rights reserved. 
mephenesin; article; hair; pigment disorder; HAIR; MEPHENESIN; PIGMENTATION DISORDERS; Hair; Mephenesin; Pigmentation Disorders 
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