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7501667 
Journal Article 
The interaction of carbamates with acetylcholinesterase 
Watts, P; Wilkinson, RG 
1977 
Yes 
Biochemical Pharmacology
ISSN: 0006-2952
EISSN: 1873-2968 
26 
8 
757-761 
English 
It has been shown that the kinetic schemes proposed by earlier workers to describe the reactions of carbamates with acetylcholinesterase are incomplete. A reaction scheme has been developed and tested by the use of methyl- and dimethyl-carbamoylcholines; it adequately explains the reactions observed in the carbamate-enzyme system, including the catalysis of decarbamoylation of carbamoylated acetylcholinesterase by excess carbamate. This study has been extended to include the reaction of acetylcholinesterase with more complex carbamates. pyridostigmine, physostigmine. mobam and decarbofuran. © 1977. 
acetylcholinesterase; carbofuran; erythrocyte enzyme; methylcarbachol; physostigmine; pyridostigmine; dimethylcarbamylcholine; drug interaction; in vitro study; mobam; potentiometry; theoretical study; titrimetry; Acetylcholinesterase; Animal; Benzofurans; Carbachol; Carbamates; Cattle; Erythrocytes; Insecticides, Carbamate; Kinetics; Physostigmine; Pyridostigmine Bromide 
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