US EPA

7501870 

Journal Article 

Fate in Rats of the Radiocarbon from Ten Variously Labeled Methyl- and Dimethyl-carbamate-C14 Insecticide Chemicals and Their Hydrolysis Products 

Krishna, JG; Casida, JE 

1966 

Yes 

Journal of Agricultural and Food Chemistry
ISSN: 0021-8561
EISSN: 1520-5118 

14 

2 

98-105 

English 

10.1021/jf60144a001 

The radiocarbon content of expired CO2, excrements, and certain tissues was determined, for the most part, 2 days after intraperitoneal administration to male white rats of 19 carbon-14-labeled materials, as follows: eight methylcarbamates-carbonyl-C14 two dimethyl-carbamates-carbonyl-C14; three methyl-C14-carbamates; two methylcarbamates labeled in a ring or a ring substituent; four hydrolysis products. Expired C14O2 accounted for 25 to 77% of the radioactivity administered as carbonyl-C14-labeled carbamates. Such methylcarbamates without a para-substituent in the phenyl ring gave rise to more radioactivity in the urine and less in the tissues than those with a substituent in this position. The radioactivity-distribution pattern was specific and distinctive for each methyl- and dimethylcarbamate, for each hydrolysis product, and for each of the sites of radiocarbon in the molecule. © 1966, American Chemical Society. All rights reserved.