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7503111 
Journal Article 
Enlargement of salivary glands upon the combined effect of isoproterenol and of a cholesterol synthesis inhibitor (SC-12937) 
Valle, LBS; Alonso, CC; Villa, N; Oliveira-Filho, RM 
1980 
Yes 
General Pharmacology
ISSN: 0306-3623
EISSN: 1879-0011 
11 
6 
507-511 
English 
1. 1. Rats were treated with isoproterenol (IPR) (7.3 μmol/100 g, i.p.), SC-12937 (SC) (0.52 μmol/100 g, i.p.), or both, for 15 days. 2. 2. IPR induced severe hypertrophy of salivary glands, whereas SC elicited marked reduction of total sterol content in salivary glands, liver, and serum, along with desmosterol accummulation. 3. 3. In the combined treatment, SC antagonized in part the effect of IPR on salivary glands. 4. 4. Although the isoproterenol-induced hypertrophy would appear to be partially dependent upon the nature and/or sterol tissue content, the SC-inhibiting effect on IPR action would be more likely due to the ultrastructural lesions caused by the azasterol. © 1980. 
1,3 dichloroprop 2 yl carbamate; azacosterol; cholesterol; desmosterol; isoprenaline; unclassified drug; animal experiment; electron microscopy; intraperitoneal drug administration; lipogenesis; mouth; rat; salivary gland; subcutaneous drug administration; Animal; Anticholesteremic Agents; Cholesterol; Female; Hypertrophy; Isoproterenol; Microscopy, Electron; Rats; Salivary Glands; Support, Non-U.S. Gov't 
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