US EPA

7504350 

Journal Article 

Forensic toxicological investigations on fatal cases of carbamate pesticide methomyl (Lannate®) poisoning 

Araki, M; Yonemitsu, K; Kambe, T 

1982 

0 

Nippon Hoigaku Zasshi
ISSN: 0047-1887 

36 

4 

584-588 

Japanese 

A 31-year old housewife committed suicide with her three children by taking a carbamate pesticide, Lannate in refreshments. Her 9-year-old eldest son survived, while the others had been found dead on the scene. The mediological autopsies of the mother and her 6-year-old second son were performed. There were pale red froths in the nose and mouth. Petechial hemorrhages in palpebral conjunctiva and myosis were observed. The mucous membrane of the stomach was blackish brown, markedly oedematous and congested. The lungs were heavy and congested. Microscopy disclosed no abnormalities except for oedema, congestions, and hemorrhages of various tissues due to acute circulatory failures. Methomyl, active ingredient of Lannate, in tissues was determined according to the method of Pease and Kirkland: Methomyl in the sample was extracted with organic solvents and hydrolyzed to oxime derivative (methyl-N-hydroxythioacetimidate), which was then analyzed by gas chromatograph equipped with flame photometric detector (FPD). The results of analysis were shown in Table 2. The estimated doses of methomyl ingested were approximately 55 mg/kg (2.75 g) to the mother and approximately 13 mg/kg (0.26 g) to her son, respectively. 

methomyl; pesticide; autopsy; blood and hemopoietic system; blood clotting; cardiovascular system; case report; drug analysis; drug determination; drug toxicity; fatality; forensic medicine; human; intoxication; lung edema; oral drug administration; psychological aspect; respiratory system; suicide; toxicology