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HERO ID
7530084
Reference Type
Journal Article
Title
Long-Term Exposure to Ambient PM2.5 and Increased Risk of CKD Prevalence in China
Author(s)
Li, G; Huang, J; Wang, J; Zhao, M; Liu, Y; Guo, X; Wu, S; Zhang, L
Year
2021
Is Peer Reviewed?
Yes
Journal
Journal of the American Society of Nephrology
ISSN:
1046-6673
EISSN:
1533-3450
Volume
32
Issue
2
Page Numbers
448-458
Language
English
PMID
33334736
DOI
10.1681/ASN.2020040517
Web of Science Id
WOS:000616498800018
Abstract
BACKGROUND:
Fine particulate matter (PM2.5) is an important environmental risk factor for cardiopulmonary diseases. However, the association between PM2.5 and risk of CKD remains under-recognized, especially in regions with high levels of PM2.5, such as China.
METHODS:
To explore the association between long-term exposure to ambient PM2.5 and CKD prevalence in China, we used data from the China National Survey of CKD, which included a representative sample of 47,204 adults. We estimated annual exposure to PM2.5 before the survey date at each participant's address, using a validated, satellite-based, spatiotemporal model with a 10 km×10 km resolution. Participants with eGFR <60 ml/min per 1.73 m2 or albuminuria were defined as having CKD. We used a logistic regression model to estimate the association and analyzed the influence of potential modifiers.
RESULTS:
The 2-year mean PM2.5 concentration was 57.4 μg/m3, with a range from 31.3 to 87.5 μg/m3. An increase of 10 μg/m3 in PM2.5 was positively associated with CKD prevalence (odds ratio [OR], 1.28; 95% confidence interval [CI], 1.22 to 1.35) and albuminuria (OR, 1.39; 95% CI, 1.32 to 1.47). Effect modification indicated these associations were significantly stronger in urban areas compared with rural areas, in males compared with females, in participants aged <65 years compared with participants aged ≥65 years, and in participants without comorbid diseases compared with those with comorbidities.
CONCLUSIONS:
These findings regarding the relationship between long-term exposure to high ambient PM2.5 levels and CKD in the general Chinese population provide important evidence for policy makers and public health practices to reduce the CKD risk posed by this pollutant.
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