Health & Environmental Research Online (HERO)


Print Feedback Export to File
7531140 
Journal Article 
Prognostic value of lymphovascular space invasion in endometrial cancer 
Puljiz, M; Puljiz, Ž; Danolić, D; Alvir, I; Tomica, D; Mamić, I; Vučemilo, T; Perić Balja, M; Zorica, R 
2013 
1 
Ljekarska Komora Zenicko-Dobojskog Kantona. Medicinski Glasnik
ISSN: 1840-0132
EISSN: 1840-2445 
10 
2 
288-292 
English 
23892846 
AIM: To evaluate the prognostic significance of lymphovascular space invasion (LVSI) in endometrial cancer (EC) patients.

METHODS: A total of 73 patients who underwent surgery for endometrial cancer at the University Hospital for Tumors, Zagreb, Croatia and University Hospital Centre Split, Croatia, in the period from 1999 to 2008 were evaluated.

RESULTS: Lymphovascular space invasion was identified in 58 cases (79.5%). Univariate analysis and multivariate analysis demonstrated a significant association between LVSI and EC recurrence (p=0.004; HR 0.241, CI 0.114-0.511). The median time from diagnosis to EC recurrence of patients with positive LVSI was 20 months, and the median time from diagnosis to EC recurrence of patients with negative LVSI was 86 months (relative risk of recurrence 0.24).

CONCLUSION: Lymphovascular space invasion identified on routine haematoxylin and eosin stained sections, is a significant independent predictor of endometrial cancer recurrence.