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7532544 
Journal Article 
Cytochemical study of casein-induced and nitrogen mustard accelerated amyloidosis in mice 
Kazimierczak, J 
1969 
Yes 
Acta Pathologica et Microbiologica Scandinavica
ISSN: 0365-5555 
77 
2 
201-217 
English 
4190825 
BCI:BCI197051088350 
In recent years increasing evidence has been provided indicating a cellular origin of amyloid. In a series of contributions to this topic Teilum (1952, 1954, 1956, 1957, 1964) elaborated the biphasic theory of amyloid formation in which the essential role of cells of the reliculo-endothelial system has been stressed. This author indicated that a proliferation of RNA synthetizing, pyroninophilic cells occurs in the initial, preainyloid phase, while in the second phase, PAS positive cells appear whose intracytoplasmic substance, when liberated, precipitates in situ in the form of amyloid. According to Christensen (1960) the cells responsible for amyloid formation were considered to be metalophilic and Ranlsv (1966) demonstrated their phagocytic properties. The present histochemical study of some oxidative and hydrolytic enzymes during the course of development of casein-induced amyloidosis and amyloidosis accelerated with nitrogen mustard, aims to pro- duce some more information of the functional characteristics of the cells involved in amyloid formation.