Synthesis and anticancer evaluation of some new pyrazolo[3,4-d][1,2,3]triazin-4-ones, pyrazolo[1,5-a]pyrimidines, and imidazo[1,2-b]pyrazoles clubbed with carbazole
Bondock, S; Alqahtani, S; Fouda, AM; ,
Carbazole represents as a promising template for cancer treatment as it exists in the skeleton of numerous man-made and natural anticancer agents. In this regard, new sets of novel functionalized pyrazolo[3,4-d][1,2,3]triazin-4-ones6a-eand10a-e, pyrazolo[1,5-a]pyrimidines16a,band imidazo[1,2-b]pyrazoles20a,band23a-chaving carbazole moiety were efficiently synthesized, characterized, and mechanistically discussed. They were also evaluated against three human cancer cell lines (HCT-116, HepG-2, and MCF-7) and one standard human cell line (REP1) for their in vitro anticancer activity. The results declared that seven compounds10d,10e,12b,12d,12e,16a, and23ahad potent anticancer activity, having IC(50)values in the range 2.97 to 10.31 mu M. The most effective compounds10dand10einhibited the growth of all screened cancer cell lines and did not reveal human toxicity.
