Health & Environmental Research Online (HERO)


Print Feedback Export to File
7538698 
Journal Article 
Poly(1,3,5-tris(4-ethynylphenyl)-benzene) Conjugated Polymers as Electrochemical Sensors for Hydrogen Peroxide Detection 
Qi, C; Kan, Z; Zhang, D; Tang, J; Ren, Z; Jia, X; Li, C; Wang, Fei; , 
2020 
AMER CHEMICAL SOC 
WASHINGTON 
685-690 
WOS:000514258700061 
Conjugated polymers (CPs) are becoming increasingly appealing for biological applications. Here, we report a strategy for detecting physiological species by using poly(1,3,5-tris(4-ethynylphenyl)-benzene) (PTEPB), a 1,3-diyne-linked CP. PTEPB was synthesized from 1,3,5-tris(4-ethynylphenyl)benzene (TEPB) via an oxidative coupling reaction. The electrochemical properties of PTEPB were then measured by using a representative biomarker, hydrogen peroxide (H2O2), which showed satisfactory results. Moreover, control experiments and quantum chemistry calculations were performed to analyze the microscopic mechanism of the electrode reaction. The results revealed that the specific active sites were the 1,3-diyne linkages in PTEPB. This method was successfully applied for the sensitive monitoring of H2O2 released from living cells, demonstrating the great potential that CPs have in the detection of physiological species.