A new Reagent for the Selective, High-Yield n-Dealkylation of Tertiary Amines: Improved Syntheses of Naltrexone and Nalbuphine | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7543926

Reference Type

Journal Article

Title

A new Reagent for the Selective, High-Yield n-Dealkylation of Tertiary Amines: Improved Syntheses of Naltrexone and Nalbuphine

Author(s)

Olofson, RA; Martz, JT; Senet, JP; Piteau, M; Malfroot, T

Year

1984

Is Peer Reviewed?

Yes

Journal

Journal of Organic Chemistry
ISSN: 0022-3263
EISSN: 1520-6904

Publisher

AMER CHEMICAL SOC

Location

WASHINGTON

Volume

Issue

Page Numbers

2081-2082

Language

English

DOI

10.1021/jo00185a072

Web of Science Id

WOS:A1984SU89400072

Abstract

Secondary amine hydrochlorides are obtained in high yield by reaction of tertiary amines with a-chloroethyl chloroformate followed by warming the intermediate carbamate in methanol. Â© 1984, American Chemical Society. All rights reserved.

Keywords

nalbuphine; naltrexone; chloroformic acid 1 chloroethyl ester; drug synthesis; methodology; nonhuman; preliminary communication; theoretical study