Health & Environmental Research Online (HERO)


Print Feedback Export to File
7545090 
Journal Article 
Improvements in the total synthesis of physostigmine: Reductive cyclization of oxindoles to tricyclic indoleninepyrrolidines with lithium aluminum hydride in tetrahydrofuran 
Yu, QS; Brossi, A 
1988 
Yes 
Heterocycles
ISSN: 0385-5414 
PERGAMON-ELSEVIER SCIENCE LTD 
OXFORD 
27 
7 
1709-1712 
English 
WOS:A1988P337700024 
Reductive cyclization of oxindole 2 and carbamate 5 with LAH in THF afforded the indoleninepyrrolidines 7 and 11 in high yield. The former compound is an important intermediate in our synthesis of (-)- and (+)-physostigmine (optical isomers of 12). Menthylcarbamates 6 and 9 prepared from 4 and 7 with menthyl chloroformate could not be separated respectively on TCL by standard techniques. © 1988. 
Other
• Harmful Algal Blooms- Health Effects
     April 2021 Literature Search
          Scopus