Synthesis and potential anthelmintic activity of methyl-5-(4-salicyloyl-piperazin-1-yl)-benzimidazole-2-carbamates | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7545909

Reference Type

Journal Article

Title

Synthesis and potential anthelmintic activity of methyl-5-(4-salicyloyl-piperazin-1-yl)-benzimidazole-2-carbamates

Author(s)

Ravina, E; Sanchez-Alonso, R; Fueyo, J; Baltar, MP; Bos, J; Iglesias, R; Sanmartin, ML

Year

1993

Is Peer Reviewed?

Journal

Arzneimittel-Forschung
ISSN: 0004-4172
EISSN: 1616-7066

Volume

Issue

Page Numbers

689-694

Language

English

Abstract

A series of methyl-5-(4-salicyloyl-piperazin-1-yl)-benzimidazole-2-carbamates (IX) has been prepared. 5-(4-salicyloyl-piperazin-1-yl)-2-nitro anilines (VII) have been synthesized starting from 5-piperazino-2-nitro anilines and salicyloyl chlorides. Catalytic reduction of VII with Pd/C, followed by treatment with 1,3-dicarbomethoxy-S-methyl isothiourea, yielded the corresponding carbamates (IX), the anthelmintic activity of which was studied. Compound IX(a) significantly reduced the numbers of preadults, adults and encysted T. spiralis larvae in experimental mice.

Keywords

anthelmintic drugs; methyl-5-(4-salicyloyl-piperazin-1-yl)-benzimidazole-2-carbamate s, pharmacology, synthesis; anthelmintic agent; methyl 5 (4 salicyloyl piperazin 1 yl)benzimidazole 2 carbamate derivative; unclassified drug; animal model; animal tissue; anthelmintic activity; article; caenorhabditis elegans; controlled study; drug synthesis; experimental infection; histology; mass spectrometry; mouse; nonhuman; nuclear magnetic resonance; oral drug administration; priority journal; trichinella spiralis; Animal; Anthelmintics; Benzimidazoles; Caenorhabditis elegans; Carbamates; Mice; Mice, Inbred Strains; Muscles; Support, Non-U.S. Gov't; Trichinella spiralis; Trichinosis