Synthesis of 2- {bis-(2-chloroethyl)amino)methyl -6,8-dinitro-1-(4-substituted phenyl)-1H-quinazolin-4-one derivatives as possible antineoplastic agents | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7546424

Reference Type

Journal Article

Title

Synthesis of 2- {bis-(2-chloroethyl)amino)methyl -6,8-dinitro-1-(4-substituted phenyl)-1H-quinazolin-4-one derivatives as possible antineoplastic agents

Author(s)

Murugan, V; Kulkarni, M; Anand, RM; Kumar, EP; Suresh, B; Reddy, VM

Year

2006

Is Peer Reviewed?

Yes

Journal

Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X

Volume

Issue

Page Numbers

900-906

Web of Science Id

WOS:000236683600021

URL

http://://WOS:000236683600021
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Abstract

Synthesis of six 2-{[bis-(2-chloroethyl)amino]methyl}-6,8-dinitro-1-(4substituted)- 1H-quinazoline-4-one derivatives is reported. The compounds contain nitro groups at positions 6 and 8 of quinazolinone moiety and a phenyl group at position 1. All the six compounds were incorporated with nitrogen mustard moiety. The synthesized compounds were screened for their anticancerous activity by short-term in vitro antitumor activity and in vivo anticancer activity by body weight analysis, mean survival time and percentage increase in life span methods in Swiss albino mice bearing DLA 1 x 10(6) cells/mL. Out of six compounds studied, compound IIIc (nitro-derivatives) showed significant anticancer activity.